L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34092791.
- Also identified by DOI 10.1038/s41592-021-01174-8 and PMC identifier 9075416.
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Abstract
L1CAM is a transmembrane protein expressed on neurons that was presumed to be found on neuron-derived extracellular vesicles (NDEVs) in human biofluids. We developed a panel of single-molecule array assays to evaluate the use of L1CAM for NDEV isolation. We demonstrate that L1CAM is not associated with extracellular vesicles in human plasma or cerebrospinal fluid and therefore recommend against its use as a marker in NDEV isolation protocols.
Medical subject headings
- Extracellular Vesicles
- Neural Cell Adhesion Molecule L1