Magnetic field-mediated Janus particles with sustained driving capability for severe bleeding control in perforating and inflected wounds.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34095621.
- Also identified by DOI 10.1016/j.bioactmat.2021.05.006 and PMC identifier 8141897.
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Abstract
Severe bleeding in perforating and inflected wounds with forky cavities or fine voids encountered during prehospital treatments and surgical procedures is a complex challenge. Therefore, we present a novel hemostatic strategy based on magnetic field-mediated guidance. The biphasic Janus magnetic particle (MSS@Fe<sub>2</sub>O<sub>3</sub>-T) comprised aggregates of α-Fe<sub>2</sub>O<sub>3</sub> nanoparticles (Fe<sub>2</sub>O<sub>3</sub> NPs) as the motion actuator, negatively modified microporous starch (MSS) as the base hemostatic substrate, and thrombin as the loaded hemostatic drug. Before application, the particles were first wrapped using NaHCO<sub>3</sub> and then doped with protonated tranexamic acid (TXA-NH<sub>3</sub> <sup>+</sup>), which ensured their high self-dispersibility in liquids. During application, the particles promptly self-diffused in blood by bubble propulsion and travelled to deep bleeding sites against reverse rushing blood flow under magnetic guidance. <i>In vivo</i> tests confirmed the superior hemostatic performance of the particles in perforating and inflected wounds ("V"-shaped femoral artery and "J"-shaped liver bleeding models). The present strategy, for the first time, extends the range of magnetically guided drug carriers to address the challenges in the hemorrhage control of perforating and inflected wounds.