PFC mTOR signaling as a biological signature for cognitive deficits in bipolar disorder without psychosis.

Radulovic, Jelena; Gabbay, Vilma · Cell Rep Med · 2021

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Abstract

Vanderplow et al.<sup>1</sup> report decreased PFC Akt-mTOR signaling in males with bipolar disorder (BD) without psychosis compared with those with psychosis, possibly related to cognitive deficits. Understanding how cognition differs between these BD subtypes clinically and biologically remains a challenge.

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