What combines best with GLP-1 for obesity treatment: GIP receptor agonists or antagonists?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34095885.
- Also identified by DOI 10.1016/j.xcrm.2021.100284 and PMC identifier 8149460.
- Licence recorded as CC BY-NC-ND.
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Abstract
Lu et al.<sup>1</sup> previously demonstrated that antagonist antibodies against the GIP receptor promote weight loss combined with GLP-1. They now elegantly developed a conjugate of GIPR antibodies and GLP-1 and show effective weight loss in obese non-human primates.
Medical subject headings
- Gastric Inhibitory Polypeptide
- Glucagon-Like Peptide 1