Tumor suppressor p53 regulates intestinal type 2 immunity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34099671.
- Also identified by DOI 10.1038/s41467-021-23587-x and PMC identifier 8184793.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The role of p53 in tumor suppression has been extensively studied and well-established. However, the role of p53 in parasitic infections and the intestinal type 2 immunity is unclear. Here, we report that p53 is crucial for intestinal type 2 immunity in response to the infection of parasites, such as Tritrichomonas muris and Nippostrongylus brasiliensis. Mechanistically, p53 plays a critical role in the activation of the tuft cell-IL-25-type 2 innate lymphoid cell circuit, partly via transcriptional regulation of Lrmp in tuft cells. Lrmp modulates Ca<sup>2+</sup> influx and IL-25 release, which are critical triggers of type 2 innate lymphoid cell response. Our results thus reveal a previously unrecognized function of p53 in regulating intestinal type 2 immunity to protect against parasitic infections, highlighting the role of p53 as a guardian of immune integrity.
Medical subject headings
- Immunity, Innate
- Intestines
- Nippostrongylus
- Parasitic Diseases
- Tritrichomonas
- Tumor Suppressor Protein p53