Ibrutinib Restores Tumor-specific Adaptive Immunity in Chronic Lymphocytic Leukemia.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 34108178.
- Also identified by DOI 10.1158/1078-0432.CCR-21-1589.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Chronic lymphocytic leukemia (CLL) is characterized by early and profound immune suppression and reversal of these effects is essential to improve patient outcome. Targeted therapy with small-molecule inhibitors such as ibrutinib is highly effective and tolerable. Emerging data suggest that patients with CLL responding to ibrutinib therapy can recover anti-CLL adaptive immune cytotoxicity.<i>See related article by Baptista et al., p. 4624</i>.
Medical subject headings
- Leukemia, Lymphocytic, Chronic, B-Cell