Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34117259.
- Also identified by DOI 10.1038/s41536-021-00145-z and PMC identifier 8195980.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.