COVID-19 mRNA Vaccination Generates Greater Immunoglobulin G Levels in Women Compared to Men.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 34117873.
- Also identified by DOI 10.1093/infdis/jiab314 and PMC identifier 8536925.
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Abstract
We investigated whether the antibody response to coronavirus disease 2019 (COVID-19) mRNA vaccination is similar in women and men. In a community cohort without prior COVID-19, first vaccine dose produced higher immunoglobulin G (IgG) levels and percent inhibition of spike-ACE2 receptor binding, a surrogate measure of virus neutralization, in women compared to men (7.0 µg/mL, 51.6% vs 3.3 µg/mL, 36.4%). After 2 doses, IgG levels remained significantly higher for women (30.4 µg/mL) compared to men (20.6 µg/mL), while percent inhibition was similar (98.4% vs 97.7%). Sex-specific antibody response to mRNA vaccination informs future efforts to understand vaccine protection and side effects.
Medical subject headings
- COVID-19
- COVID-19 Vaccines
- Immunoglobulin G
- Vaccines, Synthetic