Homing in on genomic instability as a therapeutic target in cancer.
Level V
Where this comes from
- Record sourced from PubMed, PMID 34135330.
- Also identified by DOI 10.1038/s41467-021-23965-5 and PMC identifier 8209011.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
While genomic instability is a hallmark of cancer, its genetic vulnerabilities remain poorly understood. Identifying strategies that exploit genomic instability to selectively target cancer cells is a central challenge in cancer biology with major implications for anti-cancer drug development.
Medical subject headings
- Genomic Instability
- Neoplasms