Pertussis Toxin Promotes Pulmonary Hypertension in an Infant Mouse Model of Bordetella pertussis Infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34145457.
- Also identified by DOI 10.1093/infdis/jiab325 and PMC identifier 8730479.
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Abstract
Pertussis, caused by Bordetella pertussis, is a reemerging disease that can produce severe disease manifestations in infants, including pulmonary hypertension (PH). B. pertussis-induced PH is a major risk factor for infection-induced death, but the molecular mechanisms promoting PH are unknown and there is no effective treatment. We examined B. pertussis-induced PH in infant and adult mouse models of pertussis by Fulton index, right heart catheterization, or Doppler echocardiogram. Our results demonstrate that B. pertussis-induced PH is age related and dependent on the expression of pertussis toxin by the bacterium. Hence, pertussis toxin-targeting treatments may ameliorate PH and fatal infant infection.
Medical subject headings
- Bordetella Infections
- Bordetella pertussis
- Hypertension, Pulmonary
- Pertussis Toxin