Genetic Causes of Hearing Loss in a Large Cohort of Cochlear Implant Recipients.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 34154485.
- Also identified by DOI 10.1177/01945998211021308 and PMC identifier 9128025.
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Abstract
Understanding genetic causes of hearing loss can determine the pattern and course of a patient's hearing loss and may also predict outcomes after cochlear implantation. Our goal in this study was to evaluate genetic causes of hearing loss in a large cohort of adults and children with cochlear implants. We performed comprehensive genetic testing on all patients undergoing cochlear implantation. Of the 459 patients included in the study, 128 (28%) had positive genetic testing. In total, 44 genes were identified as causative. The top 5 genes implicated were <i>GJB2</i> (20, 16%), <i>TMPRSS3</i> (13, 10%), <i>SLC26A4</i> (10, 8%), <i>MYO7A</i> (9, 7%), and <i>MT-RNR1</i> (7, 5%). Pediatric patients had a higher diagnostic rate. This study lays the groundwork for future studies evaluating the relationship between genetic variation and cochlear implant performance.
Medical subject headings
- Cochlear Implantation
- Cochlear Implants
- Deafness
- Hearing Loss