APOL1-associated kidney disease in northern Nigerians with treated HIV infection.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 34154709.
- Also identified by DOI 10.1016/j.kint.2021.04.023 and PMC identifier 9827565.
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Abstract
Apolipoprotein L1 (APOL1) high-risk genotypes strongly associate with HIV-associated nephropathy, and antiretroviral therapy reduces the incidence of HIV-associated nephropathy and progression to end-stage kidney disease. Wudil et al. report cross-sectional APOL1 associations with proteinuria and estimated glomerular filtration rate in a northern Nigerian sample with HIV infection on antiretroviral therapy. Multiple ethnic groups with different APOL1 risk variant frequencies were included. Overall, APOL1 was associated with proteinuric chronic kidney disease; however, relationships with underlying causes of nephropathy and progression rates require further study.
Medical subject headings
- Apolipoprotein L1
- HIV Infections