Ni-catalyzed hydroaminoalkylation of alkynes with amines.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34155203.
- Also identified by DOI 10.1038/s41467-021-24032-9 and PMC identifier 8217523.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Allylic amines are versatile building blocks in organic synthesis and exist in bioactive compounds, but their synthesis via hydroaminoalkylation of alkynes with amines has been a formidable challenge. Here, we report a late transition metal Ni-catalyzed hydroaminoalkylation of alkynes with N-sulfonyl amines, providing a series of allylic amines in up to 94% yield. Double ligands of N-heterocyclic carbene (IPr) and tricyclohexylphosphine (PCy<sub>3</sub>) effectively promote the reaction.