p38 MAPKs - roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 34156029.
- Also identified by DOI 10.1172/jci.insight.149915 and PMC identifier 8262482.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
p38 MAPKs play a central role in orchestrating the cellular response to stress and inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have been pursued as potential therapies for several disease indications due to their antiinflammatory properties, although none have been approved to date. Here, we provide a brief overview of p38 MAPKs, including their role in regulating myogenesis and their association with disease progression. Finally, we discuss targeting p38 MAPKs as a therapeutic approach for treating facioscapulohumeral muscular dystrophy and other muscular dystrophies by addressing multiple pathological mechanisms in skeletal muscle.
Medical subject headings
- MAP Kinase Signaling System
- Muscle, Skeletal
- p38 Mitogen-Activated Protein Kinases