Inflammation and Stroke Risk: A New Target for Prevention.

Kelly, Peter J; Lemmens, Robin; Tsivgoulis, Georgios · Stroke · 2021

review · Level V

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Abstract

New therapeutic approaches are required for secondary prevention of residual vascular risk after stroke. Diverse sources of evidence support a causal role for inflammation in the pathogenesis of stroke. Randomized controlled trials of anti-inflammatory agents have reported benefit for secondary prevention in patients with coronary disease. We review the data from observational studies supporting a role for inflammation in pathogenesis of stroke, overview randomized controlled trials of anti-inflammatory therapy in cardiac disease and discuss the potential implications for stroke prevention therapy.

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