fastsimcoal2: demographic inference under complex evolutionary scenarios.
other · Level V
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- Record sourced from PubMed, PMID 34164653.
- Also identified by DOI 10.1093/bioinformatics/btab468 and PMC identifier 8665742.
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Abstract
fastsimcoal2 extends fastsimcoal, a continuous time coalescent-based genetic simulation program, by enabling the estimation of demographic parameters under very complex scenarios from the site frequency spectrum under a maximum-likelihood framework. Other improvements include multi-threading, handling of population inbreeding, extended input file syntax facilitating the description of complex demographic scenarios, and more efficient simulations of sparsely structured populations and of large chromosomes. fastsimcoal2 is freely available on http://cmpg.unibe.ch/software/fastsimcoal2/. It includes console versions for Linux, Windows and MacOS, additional scripts for the analysis and visualization of simulated and estimated scenarios, as well as a detailed documentation and ready-to-use examples.
Medical subject headings
- Genetics, Population
- Software