Variants of Concern Are Overrepresented Among Postvaccination Breakthrough Infections of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Washington State.

McEwen, Abbye E; Cohen, Seth; Bryson-Cahn, Chloe; Liu, Catherine; Pergam, Steven A; Lynch, John; Schippers, Adrienne; Strand, Kathy et al. · Clin Infect Dis · 2022

case_series · Level IV

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Abstract

Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOCs) and had a median Ct of 20.2 (IQR, 17.1-23.3). When compared with 5174 contemporaneous samples sequenced in our laboratory, VOCs were significantly enriched among breakthrough infections (P < .05).

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