Channeling plant immunity.

Ngou, Bruno Pok Man; Ding, Pingtao; Jones, Jonathan D G · Cell · 2021

basic_science · Level V

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Abstract

Plant intracellular NLR proteins detect pathogen effectors and then form multimeric protein complexes ("resistosomes") that activate immune responses and cell death through unknown mechanisms. In this issue of Cell, Bi et al. show that the ZAR1 resistosome exhibits cation channel activity, enabling calcium influx that activates defense mechanisms and culminates in cell death.

Medical subject headings