Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 34183654.
- Also identified by DOI 10.1038/s41467-021-24220-7 and PMC identifier 8238986.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Neuroinflammation is associated with Alzheimer's disease, but the application of cerebrospinal fluid measures of inflammatory proteins may be limited by overlapping pathways and relationships between them. In this work, we measure 15 cerebrospinal proteins related to microglial and T-cell functions, and show them to reproducibly form functionally-related groups within and across diagnostic categories in 382 participants from the Alzheimer's Disease Neuro-imaging Initiative as well participants from two independent cohorts. We further show higher levels of proteins related to soluble tumor necrosis factor receptor 1 are associated with reduced risk of conversion to dementia in the multi-centered (p = 0.027) and independent (p = 0.038) cohorts of people with mild cognitive impairment due to predicted Alzheimer's disease, while higher soluble TREM2 levels associated with slower decline in the dementia stage of Alzheimer's disease. These inflammatory proteins thus provide prognostic information independent of established Alzheimer's markers.
Medical subject headings
- Alzheimer Disease
- Cerebrospinal Fluid Proteins
- Membrane Glycoproteins
- Receptors, Tumor Necrosis Factor, Type I