A Mesoscale Computational Model for Microvascular Oxygen Transfer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34184146.
- Also identified by DOI 10.1007/s10439-021-02807-x.
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Abstract
We address a mathematical model for oxygen transfer in the microcirculation. The model includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen transport in the blood and the tissue, including capillary-tissue exchange effects. Moreover, the model is suited to handle arbitrarily complex vascular geometries. The purpose of this study is the validation of the model with respect to classical solutions and the further demonstration of its adequacy to describe the heterogeneity of oxygenation in the tissue microenvironment. Finally, we discuss the importance of these effects in the treatment of cancer using radiotherapy.
Medical subject headings
- Blood Flow Velocity
- Microcirculation
- Models, Cardiovascular
- Oxygen Consumption