In-depth proteomics analysis of sentinel lymph nodes from individuals with endometrial cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34195683.
- Also identified by DOI 10.1016/j.xcrm.2021.100318 and PMC identifier 8233695.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Endometrial cancer (EC) is one of the most common gynecological cancers worldwide. Sentinel lymph node (SLN) status could be a major prognostic factor in evaluation of EC, but several prospective studies need to be performed. Here we report an in-depth proteomics analysis showing significant variations in the SLN protein landscape in EC. We show that SLNs are correlated to each tumor grade, which strengthens evidence of SLN involvement in EC. A few proteins are overexpressed specifically at each EC tumor grade and in the corresponding SLN. These proteins, which are significantly variable in both locations, should be considered potential markers of overall survival. Five major proteins for EC and SLN (PRSS3, PTX3, ASS1, ALDH2, and ANXA1) were identified in large-scale proteomics and validated by immunohistochemistry. This study improves stratification and diagnosis of individuals with EC as a result of proteomics profiling of SLNs.
Medical subject headings
- Aldehyde Dehydrogenase, Mitochondrial
- Annexin A1
- C-Reactive Protein
- Endometrial Neoplasms
- Sentinel Lymph Node
- Serum Amyloid P-Component
- Trypsin