Releasing the brake on protein synthesis in hematopoietic stem cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34214436.
- Also identified by DOI 10.1016/j.stem.2021.06.003.
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Abstract
Protein synthesis regulation constitutes a key node in directing decisions between hematopoietic stemness and differentiation. In this issue of Cell Stem Cell, Lv et al. (2021) describe a mechanism by which HSCs fine-tune translation rates by controlling 60S and 40S ribosomal subunit joining through targeted degradation of ZNF622 in response to stress.
Medical subject headings
- Hematopoietic Stem Cells