FEF_25-75% Is a More Sensitive Measure Reflecting Airway Dysfunction in Patients with Asthma: A Comparison Study Using FEF_25-75% and FEV₁.

Abstract

Reduced forced expiratory flow between 25% and 75% of vital capacity percent predicted (FEF_25-75%) representing small airway dysfunction (SAD) was associated with asthma development and progression. To investigate whether FEF_25-75% was superior to forced expiratory volume in 1 second in predicted (FEV₁%) in reflecting asthma features in adult patients. A retrospective spirometry dataset comprising 1801 adult patients with confirmed asthma and a subgroup of 332 patients having detailed clinical data were used to explore the association of FEF_25-75% and/or FEV₁% with clinical features of asthma. Of the 1801 subjects, FEV₁% and FEF_25-75% ranged from 136.8% to 10.2% and 127.3% to 3.1%, respectively. FEF_25-75% < 65% was present in 1,478 (82.07%) of patients. FEF_25-75% was strongly correlated with matched FEV₁% (r = 0.900, P < .001). FEF_25-75% and FEV₁% were both correlated with airway hyperresponsiveness (r = 0.436, P < .001; r = 0.367, P < .001), asthma control test score (r = 0.329, P < .001; r = 0.335, P < .001), and sputum eosinophil count (r = -0.306, P < .001; r = -0.307, P < .001). Receiver-operating characteristic curves showed that FEF_25-75% had greater value in predicting severe asthma (area under the curve: 0.84 vs 0.81, P = .018), airflow obstruction (0.97 vs 0.89, P < .001), and severe bronchial hyperresponsiveness (0.74 vs 0.69, P = .012) as compared with FEV₁%. Patients with SAD (FEF_25-75% < 65%) in the presence of normal FEV₁% exhibited higher sputum eosinophil counts and had an increased dosage of daily inhaled corticosteroids (P < .001 and P = .010) than patients with normal lung function and their FEF_25-75% values correlated with sputum eosinophil count (r = -0.419, P = .015), but not FEV₁%. FEF_25-75% represented small airway function and was more sensitive at reflecting airway hyperresponsiveness, inflammation, and disease severity as compared with FEV₁% in patients with asthma. Our data suggest further assessment of FEF_25-75% in asthma management, particularly for those with SAD who present normal FEV₁%.