The T cell receptor repertoire of tumor infiltrating T cells is predictive and prognostic for cancer survival.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 34215730.
- Also identified by DOI 10.1038/s41467-021-24343-x and PMC identifier 8253860.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.
Medical subject headings
- Lymphocytes, Tumor-Infiltrating
- Receptors, Antigen, T-Cell
- T-Lymphocytes