GPR3 sets brown fat on fire.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34233169.
- Also identified by DOI 10.1016/j.cmet.2021.06.003.
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Abstract
Activation of thermogenic adipocytes, a process canonically driven by norepinephrine through β-adrenergic receptors, presents an appealing therapeutic approach to combat obesity. Recent work by Sveidahl Johansen et al., 2021 published in Cell has identified a noncanonical mechanism of brown adipocyte activation, in which lipolysis transcriptionally drives the constitutive activation of the Gs protein-coupled receptor, GPR3, to induce thermogenesis.
Medical subject headings
- Adipose Tissue, Brown
- Thermogenesis