Protective succinate-SUCNR1 metabolic stress signaling gone bad.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 34233171.
- Also identified by DOI 10.1016/j.cmet.2021.06.009.
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Abstract
The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the succinate receptor SUCNR1.
Medical subject headings
- Receptors, G-Protein-Coupled
- Succinic Acid