Commensals and immune cells speak in the language of endogenous retroviruses.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34242560.
- Also identified by DOI 10.1016/j.cell.2021.06.013.
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Abstract
How the microbiome and mucosal environment mediate homeostatic immunity in the skin is not well understood. In this issue of Cell, Lima-Junior and colleagues report that skin commensal bacteria induce endogenous retrovirus (ERV) expression and antiviral immune responses in keratinocytes, favoring the priming of beneficial commensal-specific T cell subsets that promote tissue homeostasis.
Medical subject headings
- Endogenous Retroviruses
- Microbiota