Immunological lessons from CD28 deficiency in humans.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 34242561.
- Also identified by DOI 10.1016/j.cell.2021.06.014.
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Abstract
In this issue of Cell, Casanova and colleagues examine three family members with a mutation that results in deficiency of the T cell co-stimulatory molecule CD28. These patients exhibit clinical symptoms due to human papillomavirus-2 and -4 infections, show increased levels of Epstein-Barr virus and cytomegalovirus in the blood, and respond poorly to vaccines.
Medical subject headings
- Alphapapillomavirus
- Epstein-Barr Virus Infections