Combating mosquito-borne diseases using genetic control technologies.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 34282149.
- Also identified by DOI 10.1038/s41467-021-24654-z and PMC identifier 8290041.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Mosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based solutions are sought to reduce the transmission risk of these diseases. Pathogen-blocking Wolbachia bacteria, or genome engineering-based mosquito control strategies including gene drives have been developed to address these problems, both requiring the release of modified mosquitoes into the environment. Here, we review the latest developments, notable similarities, and critical distinctions between these promising technologies and discuss their future applications for mosquito-borne disease control.
Medical subject headings
- Insecticides
- Mosquito Control
- Nucleic Acid Amplification Techniques
- Vector Borne Diseases