Effects of Treatment of Coronavirus Disease 2019 With Convalescent Plasma in 25 B-Cell-Depleted Patients.

Gharbharan, Arvind; GeurtsvanKessel, Corine H; Jordans, Carlijn C E; Blaauw, Marc; van der Klift, Marjolein; Hassing, Robert-Jan; Smits-Zwinkels, Marijn; Meertens, Maaike et al. · Clin Infect Dis · 2022

case_series · Level IV

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Abstract

Twenty-five B-cell-depleted patients (24 following anti-CD19/20 therapy) diagnosed with coronavirus disease 2019 had been symptomatic for a median of 26 days but remained antibody negative. All were treated with convalescent plasma with high neutralizing antibody titers. Twenty-one (84%) recovered, indicating the potential therapeutic effects of this therapy in this particular population.

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