Chirality Nanosensor with Direct Electric Readout by Coupling of Nanofloret Localized Plasmons with Electronic Transport.

Abstract

The detection of enantiopurity for small sample quantities is crucial, particularly in the pharmaceutical industry; however, existing methodologies rely on specific chiral recognition elements, or complex optical systems, limiting its utility. A nanoscale chirality sensor, for continuously monitoring molecular chirality using an electric circuit readout, is presented. This device design represents an alternative real-time scalable approach for chiral recognition of small quantity samples (less than 10³ adsorbed molecules). The active device component relies on a gold nanofloret hybrid structure, i.e., a high aspect ratio semiconductor-metal hybrid nanosystem in which a SiGe nanowire tip is selectively decorated with a gold metallic cap. The tip mechanically touches a counter electrode to generate a nanojunction, and upon exposure to molecules, a metal-molecule-metal junction is formed. Adsorption of chiral molecules at the gold tip induces chirality in the localized plasmonic resonance at the electrode-tip junction and manifests in an enantiospecific current response.