Diagnosing a periprosthetic shoulder infection: A systematic review.

Jauregui, Julio J; Tran, Andrew; Kaveeshwar, Samir; Nadarajah, Vidushan; Chaudhri, Moiuz W; Henn, R Frank; Gilotra, Mohit N; Hasan, S Ashfaq · J Orthop · 2021

systematic_review · Level I

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Abstract

The aim of this study was to systematically review the literature regarding accurate shoulder prosthetic joint infection (PJI) diagnosis. Using PRISMA guidelines, we analyzed 25 studies reporting on 5535 patients and 646 infections. <i>Cutibacterium acnes (C. acnes)</i> cultures were positive in 60% of patients. Serum markers WBC, CRP, ESR, and IL-6 appear to lack diagnostic reliability. Synovial IL-6 and alpha-defensin may be more accurate in detecting infections. Synovial IL-6 and alpha-defensin appear to have greater utility than serum markers. These may be incorporated into new criteria to accurately diagnose shoulder PJI. IV.

Anatomy