Towards a synthetic cell cycle.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 34312383.
- Also identified by DOI 10.1038/s41467-021-24772-8 and PMC identifier 8313558.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Recent developments in synthetic biology may bring the bottom-up generation of a synthetic cell within reach. A key feature of a living synthetic cell is a functional cell cycle, in which DNA replication and segregation as well as cell growth and division are well integrated. Here, we describe different approaches to recreate these processes in a synthetic cell, based on natural systems and/or synthetic alternatives. Although some individual machineries have recently been established, their integration and control in a synthetic cell cycle remain to be addressed. In this Perspective, we discuss potential paths towards an integrated synthetic cell cycle.
Medical subject headings
- Artificial Cells
- Biological Mimicry
- Cell Cycle
- DNA Replication
- Models, Genetic
- Synthetic Biology