No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 34313608.
- Also identified by DOI 10.14309/ajg.0000000000001377 and PMC identifier 8560155.
- Licence recorded as CC BY-NC-ND.
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Abstract
The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. After adjusting for confounders, such as over health status and longstanding diseases, the regular use of PPIs was not associated with an increased risk of all-cause mortality and mortality due to neoplasms, circulatory system diseases, respiratory system diseases, digestive system diseases, external causes, and other causes. Regular use of PPIs was not associated with an increased risk of all-cause and cause-specific mortality.
Medical subject headings
- Cause of Death
- Proton Pump Inhibitors