Comment on "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34326206.
- Also identified by DOI 10.1126/science.abj1696.
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Abstract
Yoshino <i>et al</i> (Reports, 11 June 2021, p. 1224) have reported that nicotinamide mononucleotide (NMN) increases muscle insulin sensitivity in prediabetic women. However, the 13 women who received NMN had hepatic lipid content of 6.3 ± 1.2%, whereas the 12 in the placebo group had 14.8 ± 2.0% (<i>P</i> = 0.003). Given that a target of NMN is liver fat clearance, this was not an effectively randomized trial.
Medical subject headings
- Insulin Resistance
- Prediabetic State