BioERP: biomedical heterogeneous network-based self-supervised representation learning approach for entity relationship predictions.

Abstract

Predicting entity relationship can greatly benefit important biomedical problems. Recently, a large amount of biomedical heterogeneous networks (BioHNs) are generated and offer opportunities for developing network-based learning approaches to predict relationships among entities. However, current researches slightly explored BioHNs-based self-supervised representation learning methods, and are hard to simultaneously capturing local- and global-level association information among entities. In this study, we propose a BioHN-based self-supervised representation learning approach for entity relationship predictions, termed BioERP. A self-supervised meta path detection mechanism is proposed to train a deep Transformer encoder model that can capture the global structure and semantic feature in BioHNs. Meanwhile, a biomedical entity mask learning strategy is designed to reflect local associations of vertices. Finally, the representations from different task models are concatenated to generate two-level representation vectors for predicting relationships among entities. The results on eight datasets show BioERP outperforms 30 state-of-the-art methods. In particular, BioERP reveals great performance with results close to 1 in terms of AUC and AUPR on the drug-target interaction predictions. In summary, BioERP is a promising bio-entity relationship prediction approach. Source code and data can be downloaded from https://github.com/pengsl-lab/BioERP.git. Supplementary data are available at Bioinformatics online.