Butyrate, a new microbiota-dependent player in CD8+ T cells immunity and cancer therapy?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34337557.
- Also identified by DOI 10.1016/j.xcrm.2021.100328 and PMC identifier 8324458.
- Licence recorded as CC BY-NC-ND.
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Abstract
The intestinal microbiota is a new promising avenue in cancer immunotherapy, but mechanisms remain elusive. He et al. demonstrate that butyrate, a bacterial metabolite, enhances the CD8+ T cell response and improve chemotherapy efficacy through ID2-dependent IL-12 signaling.
Medical subject headings
- Gastrointestinal Microbiome
- Microbiota
- Neoplasms