CD36 pumps fat to defang killer T cells in tumors.
Where this comes from
- Record sourced from PubMed, PMID 34348095.
- Also identified by DOI 10.1016/j.cmet.2021.07.004.
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Abstract
The tumor microenvironment is immunosuppressive. Here we preview two recent studies from Ma et al. (2021) in Cell Metabolism and Xu et al. (2021) in Immunity that describe a key role of T cell-expressed CD36 in enhancing lipid uptake and mediating lipid peroxidation that ultimately leads to CD8+ T cell dysfunction, ferroptosis, and reduced anti-tumor function.
Medical subject headings
- Ferroptosis
- Neoplasms