Identifying and targeting the Achilles heel of a recalcitrant cancer.
Where this comes from
- Record sourced from PubMed, PMID 34349033.
- Also identified by DOI 10.1126/scitranslmed.abj6946.
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Abstract
Targeting replication stress response proteins in small cell lung cancer activates the innate immune cGAS-STING pathway leading to augmentation of immunotherapy's antitumor response.
Medical subject headings
- Immunity, Innate
- Lung Neoplasms
- Small Cell Lung Carcinoma