A meta-analysis for association of TNF-α -308G>A polymorphism with susceptibility to Ankylosing Spondylitis.

Mahdinejad-Yazdi, Masoud; Sobhan, Mohammad Reza; Dastgheib, Seyed Alireza; Bahrami, Reza; Shaker, Seyed Hossein; Mirjalili, Hamid; Sadeghizadeh-Yazdi, Jalal; Zare-Shehneh, Masoud et al. · J Orthop · 2021

meta_analysis · Level I

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Also identified by DOI 10.1016/j.jor.2021.07.015 and PMC identifier 8319454.
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Abstract

We performed a meta-analysis of all eligible studies on the association of TNF-α -308G>A polymorphism with risk of Ankylosing spondylitis (AS). A comprehensive literature research was performed in online databases. A total of 28 studies with 4489 cases and 5919 controls were included. Pooled ORs showed a significant association between TNF-α -308G>A polymorphism and risk of AS. Moreover, stratified analysis by ethnicity showed a significant association between TNF-α -308G>A polymorphism and AS risk in Asians, Caucasians and Mixed populations, but not in Chinese population. This meta-analysis suggested that the TNF-α -308G>A polymorphism was associated with AS risk.

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