Infection makes micro-CHIPs into macro-CHIPs.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34358435.
- Also identified by DOI 10.1016/j.stem.2021.07.006.
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Abstract
In this issue of Cell Stem Cell, Hormaechea-Agulla et al. (2021) demonstrate that IFNγ signaling following an infection in mice provides a selective pressure that drives growth of Dnmt3a<sup>-/-</sup> hematopoietic stem cells. This clonal expansion is mediated by global methylation changes that lead to an increased self-renewing capacity.
Medical subject headings
- DNA (Cytosine-5-)-Methyltransferases
- Hematopoietic Stem Cells