Race to the bottom: Darwinian competition in early intestinal tumorigenesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 34358438.
- Also identified by DOI 10.1016/j.stem.2021.07.008.
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Abstract
Mutant oncogenes could enable clonal dominance by cell-intrinsic means or by suppressing nearby wild-type stem cells. Reporting recently in Nature, three groups demonstrate potent neighborhood effects, both within intestinal crypts (Flanagan et al., 2021; van Neerven et al., 2021) and across crypts through intermediary sub-epithelial trophocytes (Yum et al., 2021).
Medical subject headings
- Cell Transformation, Neoplastic
- Intestines