Polyamine: A metabolic compass for T helper cell fate direction.
editorial · Level V
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- Record sourced from PubMed, PMID 34358466.
- Also identified by DOI 10.1016/j.cell.2021.07.012.
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Abstract
Interplay between metabolic and epigenetic remodeling may be key to cell fate control. In this issue of Cell, Puleston et al. and Wagner et al. use metabolomic, computational, and genetic approaches to uncover that polyamine metabolism directs T helper cell lineage choices, epigenetic state, and pathogenic potential in inflammation.
Medical subject headings
- Polyamines
- T-Lymphocytes, Helper-Inducer