Multifaceted mechanisms mediating cystine starvation-induced ferroptosis.
Where this comes from
- Record sourced from PubMed, PMID 34373463.
- Also identified by DOI 10.1038/s41467-021-25159-5 and PMC identifier 8352933.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.
Medical subject headings
- Ferroptosis