How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer.
Level V
Where this comes from
- Record sourced from PubMed, PMID 34400619.
- Also identified by DOI 10.1038/s41467-021-24847-6 and PMC identifier 8367998.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Synthetic glucocorticoids serve as co-medication against solid malignant tumors. However, glucocorticoid receptor activation may promote unsolicited cancer resistance to chemotherapy. The Kang team elucidated a glucocorticoid receptor-centred chemotherapy-resistance mechanism to cisplatin and characterized avenues towards a viable escape strategy.
Medical subject headings
- Neoplasms
- Receptors, Glucocorticoid