Electrochemical borylation of carboxylic acids.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34404720.
- Also identified by DOI 10.1073/pnas.2109408118 and PMC identifier 8403965.
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Abstract
A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.
Medical subject headings
- Boronic Acids
- Carboxylic Acids
- Electrochemical Techniques
- Electrodes