Analytical approximations for the speed of pacemaker-generated waves.
basic_science · Level V
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- Record sourced from PubMed, PMID 34412213.
- Also identified by DOI 10.1103/PhysRevE.104.014220.
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Abstract
In oscillatory media, waves can be generated by pacemaker regions which oscillate faster than their surroundings. In many chemical and biological systems, such waves can synchronize the whole medium and as such they are a means of transmitting information at a fixed speed over large distances. In this paper, we apply analytical tools to investigate the factors that determine the speed of these waves. More precisely, we apply singular perturbation and phase reduction methods to two types of negative-feedback oscillators, one built on underlying bistability and one including a time delay in the negative feedback. In both systems, we investigate the influence of time-scale separation on the resulting wave speed, as well as the effect of size and frequency of the pacemaker region. We compare our analytical estimates to numerical simulations which we described previously [J. Rombouts and L. Gelens, Phys. Rev. Research 2, 043038 (2020)2643-156410.1103/PhysRevResearch.2.043038].