Estrogen receptor Alpha in human knee articular cartilage of healthy and osteoarthritic females.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 34413582.
- Also identified by DOI 10.1016/j.jor.2021.08.005 and PMC identifier 8363761.
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Abstract
Estrogen and osteoarthritis association has previously been proposed. This study evaluates the presence of estrogen receptors (ER)-α in articular cartilage, and its association. A prospective cohort study of women undergoing anterior cruciate ligament reconstruction (controls) or total knee arthroplasty (cases) was performed. Cartilage samples were processed and ER-α expression was quantified. Twenty patients were included: 12 cases and 8 controls. ER-α expression was higher in the case subjects. Increased ER-α expression is associated with age, and degeneration. This suggests estrogen deficiency is a risk for osteoarthritis and is inversely related to proliferative looking chondrocytes.
Anatomy
- knee