Partners with a killer: Metabolic signaling promotes inflammatory cell death.
editorial · Level V
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- Record sourced from PubMed, PMID 34416144.
- Also identified by DOI 10.1016/j.cell.2021.07.036 and PMC identifier 9847695.
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Abstract
In this issue of Cell, Evavold et al. (2021) report that mTOR Complex 1 (mTORC1), a metabolic signaling complex, controls reactive oxygen species (ROS) production in mitochondria, which in turn promotes inflammatory cell death mediated by gasdermin D (GSDMD). This provides a new mechanistic connection between metabolic signaling and inflammatory cell death.
Medical subject headings
- Intracellular Signaling Peptides and Proteins
- Pyroptosis