Modeling neurodegeneration with mutant-tau organoids.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 34416145.
- Also identified by DOI 10.1016/j.cell.2021.07.031.
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Abstract
Greater understanding of the events preceding neurodegeneration is needed to design effective preventive and therapeutic strategies. In this issue of Cell, Bowles et al. (2021) report cerebral organoids that reveal early events in frontotemporal dementia pathogenesis due to mutations in microtubule-associated protein tau (MAPT), shedding light on a novel mechanism involving abnormal splicing and glutamate signaling.
Medical subject headings
- Frontotemporal Dementia
- Organoids